Phospholipid Metabolism in Apoptosis by Volker Lehmann, Vladimir Shatrov (auth.), Peter J. Quinn,

By Volker Lehmann, Vladimir Shatrov (auth.), Peter J. Quinn, Valerian E. Kagan (eds.)

The previous few years have witnessed an explosion of either curiosity and data approximately apoptosis, the method in which a cellphone actively commits suicide. The variety of guides at the subject has elevated from not anything within the early Eighties to greater than 10,000 papers every year this present day. it really is now good well-known that apoptosis is key in lots of features of ordinary improvement and is needed for holding tissue homeostasis. the concept existence calls for loss of life turns out a bit paradoxical, yet telephone suicide is vital for an animal to outlive. for instance, with no selective destruction of “non-self” T cells, an animal may lack immunity. equally, significant neural connections within the mind are whittled from a mass of cells. additional, developmental phone home improvement in the course of tissue maturation contains programmed mobile loss of life because the significant mechanism for practical and structural secure transition of undifferentiated cells to extra really good opposite numbers. Apoptosis study, with roots in biochemistry, developmental and telephone biology, genetics, and immunology, embraces this long-ignored usual legislations. Failure to correctly keep watch over apoptosis could have catastrophic outcomes. melanoma and lots of ailments (AIDS, Alzheimer’s illness, Parkinson’s sickness, center assault, stroke, and so on. ) are proposal to come up from deregulation of apoptosis. As apoptosis emerges as a key organic regulatory mechanism, it has turn into more durable and tougher to maintain with new advancements during this field.

Show description

Read Online or Download Phospholipid Metabolism in Apoptosis PDF

Best nonfiction_9 books

Ciba Foundation Symposium 30 - The Future of Philanthropic Foundations

Content material: bankruptcy 1 advent (pages 1–2): Lord ToddChapter 2 Foundations and Their Fields (pages 3–15): John Z. BowersChapter three Independence, Scale and test: the event of the Ciba origin (pages 17–30): G. E. W. WolstenholmeChapter four Foundations and the kingdom within the Federal Republic of Germany: a few reviews (pages 31–33): G.


The new overseas alarm on the attainable use of smallpox as weapon of bioterror has refocused the eye of the medical neighborhood, public future health coverage makers and the general public on poxviruses. unlike the chance posed via a few of these viruses, different poxviruses convey fascinating worthwhile strength together with their use as priceless instruments in biomedical examine and within the supply of vaccines.

Optical Networks. A Practical Perspective

''This e-book isn't just thorough in protecting the physics and the purposes of optical communications, however it discusses the relevance of know-how to the rising clever optical networking revolution. this could be necessary interpreting for each specialist in our company. '' —Desh Deshpande, Chairman, Sycamore Networks, Inc.

Calcium Signaling In Airway Smooth Muscle Cells

This ebook explores the position calcium signaling performs in mobile responses in just about all different types of cells together with airway soft muscle cells. This common signaling may end up from extracellular calcium inflow and/or intracellular calcium liberate, that are accurately managed and controlled by means of ion channels, exchangers and/or transporters at the plasmalemmal or sarcoplasmic reticulum membrane.

Extra info for Phospholipid Metabolism in Apoptosis

Example text

We concluded, therefore, that the enhanced peroxidation reactions are responsible for geranylgeranoic acid-induced apoptosis. In the literature, most drug-induced apoptosis is well known to require intracellular hyper-production of reactive oxygen species and several antioxidants inhibit apoptotic cell death. While it is clear that peroxidation reactions induce apoptosis, the precise molecular mechanism of how reactive oxygen species convey death-signals is unknown. 1 Peroxidation of cardiolipin We directed our initial attention to the mitochondrion-specific phospholipid, cardiolipin because it is particularly rich in polyunsaturated fatty acids which are vulnerable to oxidative attack.

Spin-labelled analogs have also been used (Seigneuret and Deveaux, 1984). , 1995). The major disadvantage of these analogs is that the reporter group introduces significant changes in lipid conformation and properties and the effect this may have on behaviour is problematic. , 44 Peter J. Quinn 1986). Methods of assessing transmembrane movement of sphingolipids have been reviewed by Sillence et al. (2000). Measurement of transmembrane movement of phospholipids using florescent or other probe methods requires demonstration that incorporation of the phospholipid analogs occurs by a monomeric transfer from an exogenous resevoir into the outer leaflet of the plasma membrane rather than a fusion of bilayer vectors containing the probes with the plasma membrane.

FEBS Lett. , 1993, Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species. Eur. J. Biochem. , 2000, Protection of mitochondrial integrity from oxidative stress by the triaminopyridine derivative flupirtine. , 1997, Rapid loss in the mitochondrial membrane potential during geranygeranoic acid-induced apoptosis. Biochem. Biophys. Res. Commun. , 1999, Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidation.

Download PDF sample

Rated 4.69 of 5 – based on 12 votes