Phenolsulfotransferase in Mental Health Research by Merton Sandler, Earl Usdin

By Merton Sandler, Earl Usdin

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2). 4 to 3-:7. 02). These results suggested that platelet PST activity might reflect the relative enzyme activity present in the human renal cortex. Experiments similar to those carried out for the kidney were performed to study the relationship between relative platelet and gut PST activities. Eight human jejunal biopsy samples were obtained over a 5 month period. One sample showed focal villous atrophy, one had increased lamina propria cells with a single crypt abcess and the remainder were histologically normal.

Second, it was not egonomically possible to use higher concentrations of 3 S-PAPS. Therefore, the values of PST activity reported here can only be compared with results obtained with similar concentrations of PAPS. Effects of dithiothreitol and bovine serum albumin. Because the activity of partially purified human erythrocyte PST was increased by the addition of dithiothreitol and bovine serum albumin (BSA), human platelet, kidney, and gut enzyme activities were measured in the presence of various concentrations of these two substances.

1979). Analysis of 3'phosphoadenylylsulphate and related compounds by paired-ion high-performance I iquid chromatography. J. , 176, 478-479. M. J. (1980). Studies on the meta and para O-sulphation of the catechol compound 3,4-dihydroxybenzoic acid by rat liver sulphotransferase in vitro. Biochem. , 191, 133-138. Pertoft, H. and Lindahl-Kiessl ing, K. (1968). Separation of various blood cells in colloidal silica-polyvinylpyrrol idone gradients. Exp. , 50, 355-368. Pharmacia Fine Chemicals (Uppsala, Sweden).

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