Man-Made Vitreous Fibres (IARC Monographs on the Evaluation by IARC

By IARC

Reviews the conclusions of a systematic operating team of nineteen specialists from eleven nations convened by way of the Monographs Programme of the overseas company for examine on melanoma (IARC) at the second look of the carcinogenic danger of airborne man-made vitreous fibres.

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A. (1990) The relationship between fibrosis and cancer in experimental animals exposed to asbestos and other fibers. Environ. , Thevenaz, P. & Anderson, R. (1993) Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats. Fundam. appl. , Lewis, S. & Britton, J. (1999) Lung cancer and cryptogenic fibrosing: A population based cohort study. Am. J. respir. crit. , 161, 5–8 IARC (1987) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl. 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, Lyon, IARCPress, pp.

5. Some Mycotoxins (IARC Scientific Publications No. 44). Edited by L. Stoloff, M. Castegnaro, P. K. O’Neill & H. qxd 06/12/02 30 15:35 Page 30 IARC MONOGRAPHS VOLUME 81 Vol. 6. N-Nitroso Compounds (IARC Scientific Publications No. 45). Edited by R. K. O’Neill, G. Eisenbrand, B. Spiegelhalder & H. Bartsch (1983) Vol. 7. Some Volatile Halogenated Hydrocarbons (IARC Scientific Publications No. 68). Edited by L. K. O’Neill (1985) Vol. 8. Some Metals: As, Be, Cd, Cr, Ni, Pb, Se, Zn (IARC Scientific Publications No.

For example, different results were obtained in two studies of refractory ceramic fibres — one study reported both fibrosis and tumorigenesis while the other reported neither fibrosis nor tumours in rats and mesothelioma in only 2% of hamsters. Many earlier studies did not appreciate the importance of fibre diameter in the respirability of fibres in the rat. In addition, fibres were often ground before administration; this procedure significantly shortened their length and often resulted in exposure of the test animals to primarily short fibres.

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