By Fredrik Öisjöen
This thesis describes the tough activity of constructing excessive severe temperature superconducting quantum interference units (high-Tc SQUIDs) and utilizing them as sensors for biomedical purposes, together with magnetic immunoassays, magnetoencephalography and magnetic resonance imaging (MRI). the 1st a part of this paintings discusses the advance of speedy magnetic immunoassays, which are used to enhance the sensitivity, or to create new, specific point-of-care diagnostics platforms. the second one half exhibits that high-Tc SQUIDs may perhaps make magnetoencephalography extra to be had, hence starting the sector of high-Tc SQUID-based magnetoencephalography for recording mind capabilities. this system may be mixed with ultra-low box MRI that is mentioned within the final half. this mix could provide a brand new particular software for reports of mind capabilities. This paintings doesn't easily enhance on present know-how yet opens chances for novel complex scientific units and techniques.
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Additional resources for High-Tc SQUIDs for Biomedical Applications: Immunoassays, Magnetoencephalography, and Ultra-Low Field Magnetic Resonance Imaging
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64 Hz 10 Hz 22 SQUID Signal (mΦ0/μg MNPs) Fig. 11 Microdroplet optimization calibration. The highest signal/mass of MNPs was found to be for 2 µl droplets. This data was measured with GRAD5 3 Magnetic Immunoassays 20 18 16 14 12 10 0 1 2 3 4 Sample Volume (μl) Glycerol Dilution In order to verify our system and our measurement techniques a method of controlling the change in relaxation dynamics of a MNP sample was required. The expression for the Brownian relaxation time that was presented in Eq.
Gradiometers 4-5 (GRAD4-5) were fabricated on a STO bicrystal (24◦ misorientation angle) substrate with a 50 nm CeO2 seed-layer. The flux noise of the GRAD4 is shown in Fig. 19 measured with and without shielding with dc-bias and bias reversal. The critical current of this SQUID was 220 µA with Ic Rn = 176 µV, and the voltage modulation was 22 µV at 77 K. Lastly, GRAD6 was a single gradiometer on a 10×10 mm2 large STO chip with a ◦ 24 misorientation angle. The width of the junctions of the two redundant SQUIDs was 2 µm and it had flux dams in the design (see Fig.