High-Tc SQUIDs for Biomedical Applications: Immunoassays, by Fredrik Öisjöen

By Fredrik Öisjöen

This thesis describes the tough activity of constructing excessive severe temperature superconducting quantum interference units (high-Tc SQUIDs) and utilizing them as sensors for biomedical purposes, together with magnetic immunoassays, magnetoencephalography and magnetic resonance imaging (MRI). the 1st a part of this paintings discusses the advance of speedy magnetic immunoassays, which are used to enhance the sensitivity, or to create new, specific point-of-care diagnostics platforms. the second one half exhibits that high-Tc SQUIDs may perhaps make magnetoencephalography extra to be had, hence starting the sector of high-Tc SQUID-based magnetoencephalography for recording mind capabilities. this system may be mixed with ultra-low box MRI that is mentioned within the final half. this mix could provide a brand new particular software for reports of mind capabilities. This paintings doesn't easily enhance on present know-how yet opens chances for novel complex scientific units and techniques.

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Kleiner, F. Ludwig, E. Dantsker, J. Clarke, High-transition-temperature superconducting quantum interference devices. Rev. Mod. Phys. 71(3), 631–686 (1999) 14. K. K. Semenov, Fluctuation spectrum in superconducting point junctions. JETP Lett. 15(10), 625–629 (1972) 15. N. N. S. K. V. K. Semenov, S-c-S junctions as nonlinear elements of microwave receiving devices. Phys. Rev. Appl. 9, 79 (1974) 16. J. M. B. Ketchen, Tunnel junction dc SQUID: Fabrication, operation, and performance. J. Low Temp. Phys.

64 Hz 10 Hz 22 SQUID Signal (mΦ0/μg MNPs) Fig. 11 Microdroplet optimization calibration. The highest signal/mass of MNPs was found to be for 2 µl droplets. This data was measured with GRAD5 3 Magnetic Immunoassays 20 18 16 14 12 10 0 1 2 3 4 Sample Volume (μl) Glycerol Dilution In order to verify our system and our measurement techniques a method of controlling the change in relaxation dynamics of a MNP sample was required. The expression for the Brownian relaxation time that was presented in Eq.

Gradiometers 4-5 (GRAD4-5) were fabricated on a STO bicrystal (24◦ misorientation angle) substrate with a 50 nm CeO2 seed-layer. The flux noise of the GRAD4 is shown in Fig. 19 measured with and without shielding with dc-bias and bias reversal. The critical current of this SQUID was 220 µA with Ic Rn = 176 µV, and the voltage modulation was 22 µV at 77 K. Lastly, GRAD6 was a single gradiometer on a 10×10 mm2 large STO chip with a ◦ 24 misorientation angle. The width of the junctions of the two redundant SQUIDs was 2 µm and it had flux dams in the design (see Fig.

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