By W. R. Hein (auth.), Professor Dr. Jean-Pierre Kraehenbuhl, Professor Dr. Marian R. Neutra (eds.)
Mucosal immunity contains a extensive box of study that comes with components of epithelial phone and molecular biology, molecular and mobile immunology, microbiology, virology, and vaccinology. This quantity provides modern and concise discussions of recommendations in addition to contemporary advances. It offers an outline of the parts of the mucosal immune approach, and the elemental technological know-how correct to mucosal vaccination. The authors determine present examine in severe components together with: association of mucosal lymphoid tissue; antigen sampling and presentation in mucosal tissues; mucosalimmune responses and tolerance; immune effectors at mucosal websites; microbial-host interactions at mucosal websites; mucosal vaccines and adjuvants. This multi-disciplinary attempt might be a worthwhile source for researchers, clinicians and scholars who want a transparent realizing of thoughts and a advisor to the wide-ranging literature during this very energetic learn area.
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Extra resources for Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines
In addition, chemokines could form gradients by binding to extracellular matrix components, thus supporting the directional migration of leukocytes toward the epithelium (MADARA 1994). These signaling mechanisms could play an indirect role in FAE differentiation by promoting the assembly of lymphoid follicles. 4 Induction of the M-Cell Phenotype in Vitro Recently, the ability of B cells to convert an enterocyte phenotype to an M-cell phenotype was directly demonstrated using a novel co-culture system (KERNElS apical chamber basal chamber m Fig.
I Cell Sci Suppl 17:27-32 Rosenshine I, Donnenberg MS, Kaper IB, Finlay BB (1992) Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake. EMBO J 11:3551-3560 Roy MJ, Varvayanis M (1987) Development of dome epithelium in gut-associated lymphoid tissues: association of IgA with M cells. Cell Tissue Res 248:645-651 Savidge TC, Smith MW (1995) Evidence that membranous (M) cell genesis is immunoregulated.
2 Ag Capture for MHC Class-I Expression. 2 Ag Capture by DCs in Vivo. 6 DC Migration . . . 1 Steady-State Migration . . 2 Stimulated Migration . . 3 Molecular Basis of DC Migration. 7 Interaction of DCs with T Cells. 4 Mucosal DLCs . . . . . . . Introduction . . . . . . . . Distribution of DCs in Mucosal Tissues Non-lymphoid Tissues. . . . . Functional Properties of Mucosal DCs . Isolation of Mucosal DCs . Kinetic Studies. . Steady State . . . . Stimulated Migration .