Celecoxib - A Medical Dictionary, Bibliography, and by Icon Health Publications

By Icon Health Publications

It is a 3-in-1 reference ebook. It offers an entire clinical dictionary protecting 1000's of phrases and expressions in relation to Celecoxib. It additionally offers vast lists of bibliographic citations. ultimately, it presents info to clients on tips on how to replace their wisdom utilizing a variety of net assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with examine devoted to Celecoxib. in case your time is efficacious, this ebook is for you. First, you won't waste time looking out the web whereas lacking loads of suitable info. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing enormous quantities of websites.

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Extra resources for Celecoxib - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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The objectives of this application are to establish the effects of a cyclooxygenase-2 (cox-2) inhibitor in: (1) inducing tumor apoptosis and reducing urine bFGF concentration, and (2) controlling the concentration of Cox products in humans with invasive TCC. The central hypothesis is cox-2 inhibitors will block the synthesis of Cox products (thereby limiting concentrations of Cox products in the tumor) and will induce apoptosis in invasive TCC in humans. The central hypothesis is based on strong preliminary data showing antitumor activity of Cox inhibitors and a strong association between the Cox inhibitor-induced tumor regression and doubling of the apoptotic index in invasive TCC in canine studies.

Secondly, we propose that selenium and celecoxib will differentially affect the CIMP status of recurrent adenomas from Project Ib. Thirdly, we will verify, again in a large population, the association of CIMP status with specific genetic alterations (Ki-ras, p53), and biologic events (COX expression, apoptosis and proliferation). Lastly, we will explore the involvement of a field defect in adenoma pathogenesis by determining the association of age-related DNA methylation and nuclear chromatin alterations in baseline rectal mucosa and the ability of these variables to predict adenoma recurrence.

Associate Professor; New England Medical Center Hospitals 750 Washington St Boston, Ma 021111533 Timing: Fiscal Year 2002; Project Start 15-AUG-2002; Project End 31-JAN-2009 Summary: (provided by applicant): Autosomal dominant polycystic kidney disease (ADPKD) is the most common lethal monogenetic disease, affecting 1/500 to 1/1000 of the US population. 50% of those affected with ADPKD will develop end-stage renal disease by the 6th decade of life. There are no proven therapies to slow the inexorable loss of kidney function in those with progressive disease.

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