Brain Dopaminergic Systems: Imaging with Positron by Yves Agid (auth.), J. C. Baron, D. Comar, L. Farde, J. L.

By Yves Agid (auth.), J. C. Baron, D. Comar, L. Farde, J. L. Martinot, B. Mazoyer (eds.)

'....the booklet is most precious in the event you are commencing to learn the mind dopaminergic method and are contemplating puppy as a tool.'Nuclear Medicine 19:9 1992

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Sample text

V . injection of the radiotracer (Martin et al. 1989). In rats 0methylated 6-[18Flfluoro-L-DOPA metabolite levels increase in plasma at a rate greater than [3Hl-L-DOPA (Melega et al. 1990) . Since 3-0-methylDOPA is a poor substrate of AADC (Ferrini and Glaser, 1964) significant contribution of this metabolite to the total radioactive pool in the brain would appearingly decrease the specific utilization by elevating "background" radioactivity. 1991c). Following COMT inhibition, the apparent rate constant of the striatal kinetic conversion of 6-fluoro-[BllCl-L-DOPA increased 60% indicating a substantial decrease in "background" radioactivity.

Mazi6re, B. and Loc'h, C. (19868) 'Radlopharmaceutlcalslabelled with bromine Isotopes', Appl. Radlat. Isot. 37, 703. , Mazl6re, M. (1986b) ,7&er-bromOlisurlde: A new tool for quantitative In vivo imaging of O2 dopamine receptors', Eur. J. Pharmacol. 127,239. , Mazi~re, M. , Neuropsychopharmacology, Springer Verlag, pp. 409-417. , and Hashimoto, M. (1988) 'Disposition and metabolism of [ 4C]haloperldol In rats', Arznelm. /Drug Research 192,291. M. and St6cklln, G. a. 75,77Br-bromperldol', J. Label.

Moreover, in the primate striatum, the rate constant of the kinetic conversion of [B_llC]-L-DOPA decreases dosedependently after pretreatment with centrally acting AADC inhibitors (Tedroff et al. 1991b, 1991c) . Similar results have also been shown for [11C]-5HTP (Hartvig et al . 1991a). This suggests that the specific striatal accumulation of radioactivity following administrat i on of radiolabelled aromatic L- amino acids grossly indicates decarboxylation of tracer and subsequent retention of the resulting amine.

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