By Baoxue Yang (eds.)
This booklet offers a state of the art record on our present realizing of aquaporins and the longer term path of the sector. Aquaporins (AQPs) are a gaggle of water-channel proteins which are in particular permeable to water and different small molecules, comparable to glycerol and urea. so far 13 water-channel proteins (AQP0 – AQP12) were cloned and the mechanisms and physiological services of water delivery throughout organic membranes have lengthy been the topic of curiosity. contemporary advances within the molecular biology and body structure of water delivery have yielded new insights into how and why water strikes throughout phone membranes, and stories on aquaporin knockout mouse versions recommend that aquaporins are serious about the improvement of a few ailments and so they can be invaluable goals of analysis into selective-inhibitor medicinal drugs. via concentrating on the advances revamped the final twenty years within the biophysics, genetics, protein constitution, molecular biology, body structure, pathophysiology and pharmacology of aquaporins in mammalian mobilephone membranes, this ebook presents novel insights into additional mechanisms and the physiological value of water and a few small molecule delivery in mammals so as to stimulate extra learn in new directions.
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Extra info for Aquaporins
Ishikawa Y, Skowronski MT, Inoue N, Ishida H (1999) alpha(1)-adrenoceptor-induced trafficking of aquaporin-5 to the apical plasma membrane of rat parotid cells. Biochem Biophys Res Commun 265:94–100 107. Itoh T, Rai T, Kuwahara M, Ko SB, Uchida S, Sasaki S, Ishibashi K (2005) Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Jenq W, Cooper DR, Bittle P, Ramirez G (1999) Aquaporin-1 expression in proximal tubule epithelial cells of human kidney is regulated by hyperosmolarity and contrast agents.
The hourglass model. Kamsteeg EJ, Hendriks G, Boone M, Konings IB, Oorschot V, van der Sluijs P, Klumperman J, Deen PM (2006) Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Katsura T, Gustafson CE, Ausiello DA, Brown D (1997) Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Phys 272:F817–F822 113. Kim HY, Choi HJ, Lim JS, Park EJ, Jung HJ, Lee YJ, Kim SY, Kwon TH (2011) Emerging role of Akt substrate protein AS160 in the regulation of AQP2 C.
Sui H, Han BG, Lee JK, Walian P, Jap BK (2001) Structural basis of water-specific transport through the AQP1 water channel. Sun TX, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D (2002) Aquaporin-2 localization in clathrin-coated pits: inhibition of endocy- C. Li and W.