Aquaporins by Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric

By Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric Beitz (eds.)

The aquaporin box has matured at a really quickly velocity and we're on the verge to strengthen severe concepts to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key must haves can be found at the present time: i. a substantial (and starting to be) variety of aquaporin crystal constructions for the rational layout of inhibitory molecules, ii. complex molecular dynamics simulation recommendations for theoretical analyses of selectivity mechanisms and docking experiments, iii. entire facts on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological experiences, and v. assay structures for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and hence covers the advancements from easy learn to strength pharmacological use. positioned among pharmacology textbooks and up to date medical papers this e-book offers a well timed review for readers from the elemental in addition to the utilized disciplines.

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1 The AQP Fold . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 The Structure of the Pore . . . . . . . . . . . . . . . . . . . . . . . . 3 Surface Structure of AQPs Involved in Membrane Junctions . . . . . . . . . 4 Unsolved Riddles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AQP Trafficking . . . . . . . . . . . . . . . . .

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 36 37 38 38 41 45 45 48 49 50 51 51 Abstract Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins. The atomic structures now available have allowed the water permeation and exclusion of protons to be monitored by molecular dynamics simulations, and have provided a framework for assessing the water and solute permeation in great detail by site-directed mutations.

4 Gas Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 36 37 38 38 41 45 45 48 49 50 51 51 Abstract Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins.

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